There are various types of scientific studies such as experiments and comparative analyses, observational studies, surveys, or interviews. The choice of study type will mainly depend on the research question being asked.
When making decisions, patients and doctors need reliable answers to a number of questions. Depending on the medical condition and patient's personal situation, the following questions may be asked:
What is the cause of the condition?
What is the natural course of the disease if left untreated?
What will change because of the treatment?
How many other people have the same condition?
How do other people cope with it?
Each of these questions can best be answered by a different type of study.
In order to get reliable results, a study has to be carefully planned right from the start. One thing that is especially important to consider is which type of study is best suited to the research question. A study protocol should be written and complete documentation of the study's process should also be done. This is vital in order for other scientists to be able to reproduce and check the results afterwards.
The main types of studies are randomized controlled trials (RCTs), cohort studies, case-control studies and qualitative studies.
Randomized controlled trials
If you want to know how effective a treatment or diagnostic test is, randomized trials provide the most reliable answers. Because the effect of the treatment is often compared with "no treatment" (or a different treatment), they can also show what happens if you opt to not have the treatment or diagnostic test.
When planning this type of study, a research question is stipulated first. This involves deciding what exactly should be tested and in what group of people. In order to be able to reliably assess how effective the treatment is, the following things also need to be determined before the study is started:
How long the study should last
How many participants are neededSee AlsoStudent Information System Software Market Size 2023-2026: Revenue, Foreign Opportunity, Application, Types, Impact of Covid-19 and Russia-Ukraine War | Research by Absolute Reports33 Types of Italian Pasta and Their Uses18 Different Types of Windows: Costs, Styles and Pictures | Modernize8 Types Of Flooring To Consider
How the effect of the treatment should be measured
For instance, a medication used to treat menopause symptoms needs to be tested on a different group of people than a flu medicine. And a study on treatment for a stuffy nose may be much shorter than a study on a drug taken to prevent strokes.
“Randomized” means divided into groups by chance. In RCTs participants are randomly assigned to one of two or more groups. Then one group receives the new drug A, for example, while the other group receives the conventional drug B or a placebo (dummy drug). Things like the appearance and taste of the drug and the placebo should be as similar as possible. Ideally, the assignment to the various groups is done "double blinded," meaning that neither the participants nor their doctors know who is in which group.
The assignment to groups has to be random in order to make sure that only the effects of the medications are compared, and no other factors influence the results. If doctors decided themselves which patients should receive which treatment, they might – for instance – give the more promising drug to patients who have better chances of recovery. This would distort the results. Random allocation ensures that differences between the results of the two groups at the end of the study are actually due to the treatment and not something else.
Randomized controlled trials provide the best results when trying to find out if there is a cause-and-effect relationship. RCTs can answer questions such as these:
Is the new drug A better than the standard treatment for medical condition X?
Does regular physical activity speed up recovery after a slipped disk when compared to passive waiting?
A cohort is a group of people who are observed frequently over a period of many years – for instance, to determine how often a certain disease occurs. In a cohort study, two (or more) groups that are exposed to different things are compared with each other: For example, one group might smoke while the other doesn't. Or one group may be exposed to a hazardous substance at work, while the comparison group isn't. The researchers then observe how the health of the people in both groups develops over the course of several years, whether they become ill, and how many of them pass away. Cohort studies often include people who are healthy at the start of the study. Cohort studies can have a prospective (forward-looking) design or a retrospective (backward-looking) design. In a prospective study, the result that the researchers are interested in (such as a specific illness) has not yet occurred by the time the study starts. But the outcomes that they want to measure and other possible influential factors can be precisely defined beforehand. In a retrospective study, the result (the illness) has already occurred before the study starts, and the researchers look at the patient's history to find risk factors.
Cohort studies are especially useful if you want to find out how common a medical condition is and which factors increase the risk of developing it. They can answer questions such as:
How does high blood pressure affect heart health?
Does smoking increase your risk of lung cancer?
For example, one famous long-term cohort study observed a group of 40,000 British doctors, many of whom smoked. It tracked how many doctors died over the years, and what they died of. The study showed that smoking caused a lot of deaths, and that people who smoked more were more likely to get ill and die.
Case-control studies compare people who have a certain medical condition with people who do not have the medical condition, but who are otherwise as similar as possible, for example in terms of their sex and age. Then the two groups are interviewed, or their medical files are analyzed, to find anything that might be risk factors for the disease. So case-control studies are generally retrospective.
Case-control studies are one way to gain knowledge about rare diseases. They are also not as expensive or time-consuming as RCTs or cohort studies. But it is often difficult to tell which people are the most similar to each other and should therefore be compared with each other. Because the researchers usually ask about past events, they are dependent on the participants’ memories. But the people they interview might no longer remember whether they were, for instance, exposed to certain risk factors in the past.
Still, case-control studies can help to investigate the causes of a specific disease, and answer questions like these:
Do HPV infections increase the risk of cervical cancer?
Is the risk of sudden infant death syndrome (“cot death”) increased by parents smoking at home?
Cohort studies and case-control studies are types of "observational studies."
Many people will be familiar with this kind of study. The classic type of cross-sectional study is the survey: A representative group of people – usually a random sample – are interviewed or examined in order to find out their opinions or facts. Because this data is collected only once, cross-sectional studies are relatively quick and inexpensive. They can provide information on things like the prevalence of a particular disease (how common it is). But they can't tell us anything about the cause of a disease or what the best treatment might be.
Cross-sectional studies can answer questions such as these:
How tall are German men and women at age 20?
How many people have cancer screening?
This type of study helps us understand, for instance, what it is like for people to live with a certain disease. Unlike other kinds of research, qualitative research does not rely on numbers and data. Instead, it is based on information collected by talking to people who have a particular medical condition and people close to them. Written documents and observations are used too. The information that is obtained is then analyzed and interpreted using a number of methods.
Qualitative studies can answer questions such as these:
How do women experience a Cesarean section?
What aspects of treatment are especially important to men who have prostate cancer?
How reliable are the different types of studies?
Each type of study has its advantages and disadvantages. It is always important to find out the following: Did the researchers select a study type that will actually allow them to find the answers they are looking for? You can’t use a survey to find out what is causing a particular disease, for instance.
It is really only possible to draw reliable conclusions about cause and effect by using randomized controlled trials. Other types of studies usually only allow us to establish correlations (relationships where it isn’t clear whether one thing is causing the other). For instance, data from a cohort study may show that people who eat more red meat develop bowel cancer more often than people who don't. This might suggest that eating red meat can increase your risk of getting bowel cancer. But people who eat a lot of red meat might also smoke more, drink more alcohol, or tend to be overweight. The influence of these and other possible risk factors can only be determined by comparing two equal-sized groups made up of randomly assigned participants.
That is why randomized controlled trials are usually the only suitable way to find out how effective a treatment is. Systematic reviews, which summarize multiple RCTs, are even better. In order to be good-quality, though, all studies and systematic reviews need to be designed properly and eliminate as many potential sources of error as possible.
German Network for Evidence-based Medicine. Glossar: Qualitative Forschung.Berlin: DNEbM; 2011.
Greenhalgh T. Einführung in die Evidence-based Medicine: kritische Beurteilung klinischer Studien als Basis einer rationalen Medizin. Bern: Huber; 2003.
Institute for Quality and Efficiency in Health Care (IQWiG, Germany). General methods. Version 5.0. Cologne: IQWiG; 2017.
Klug SJ, Bender R, Blettner M, Lange S. Wichtige epidemiologische Studientypen. Dtsch Med Wochenschr 2007; 132:e45-e47. [PubMed: 17530597]
Schäfer T. Kritische Bewertung von Studien zur Ätiologie. In: Kunz R, Ollenschläger G, Raspe H, Jonitz G, Donner-Banzhoff N (eds.). Lehrbuch evidenzbasierte Medizin in Klinik und Praxis. Cologne: Deutscher Ärzte-Verlag; 2007.
IQWiG health information is written with the aim of helpingpeople understand the advantages and disadvantages of the main treatment options and healthcare services.
Because IQWiG is a German institute, some of the information provided here is specific to theGerman health care system. The suitability of any of the described options in an individualcase can be determined by talking to a doctor. We do not offer individual consultations.(Video) What Are Observational And Experimental Studies In Statistics - Types Of Studies Explained
Our information is based on the results of good-quality studies. It is written by ateam ofhealth care professionals, scientists and editors, and reviewed by external experts. You canfind a detailed description of how our health information is produced and updated inour methods.
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- Causal Design.
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- Cross Sectional Survey. ...
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- Educational Institutes. ...
- Government Resources. ...
- Internet Data.
- Step 1: Determine what the exposure and outcome are in the given question.
- Step 2: Determine if it is an observational or experimental study by reading the question carefully.
- Step 3: Ascertain if key words give away the design (read the sub-questions carefully):
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Primary Qualitative Methods
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- 5) SAMPLE: ...
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- 8) RESULT OR OUTCOME: